Determination of VEGF and CXCR4 in Tumor and Peritumoral Tissue of Patients with Breast Cancer as a Predictive Factor

Authors

DOI:

https://doi.org/10.4108/eai.25-3-2022.173714

Keywords:

Breast cancer, Peritumoral tissue, CXCR-4, VEGF, Predictive factor

Abstract

INTRODUCTION: Despite the obvious progress in the field of diagnosis and therapy, further measures are needed to increase the effectiveness of treatment and reduce morbidity and mortality from breast cancer.

OBJECTIVES: To study the influence of peritumoral tissue on the growth and development of the tumor itself.

METHODS: An immunofluorescence method was used to determine the protein expression of VEGF and CXCR-4 in tumor and peritumoral tissue.

RESULTS: Peritumoral tissue is not only a passive factor, but actively participates in the process of tumor growth and development, as well as in the processes of recurrence and metastasis.

CONCLUSION: Markers of neoangiogenesis in tumor and peritumoral tissue such as protein expression of VEGF and CXCR-4 receptors may serve as reliable predictors of disease outcome in breast cancer patients, which may provide useful suggestions in treatment choices.

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Published

25-03-2022

How to Cite

Cvetković, D. ., Cvetković, A. ., Nikodijević, D. ., Jovankić, J. ., Milutinović, M. ., Stojić, V. ., Zdravković, N. ., & Mitrović, S. . (2022). Determination of VEGF and CXCR4 in Tumor and Peritumoral Tissue of Patients with Breast Cancer as a Predictive Factor. EAI Endorsed Transactions on Bioengineering and Bioinformatics, 1(4), e4. https://doi.org/10.4108/eai.25-3-2022.173714

Issue

Vol. 1 No. 4 (2021): EAI Endorsed Transactions on Bioengineering and Bioinformatics

Section

Research article

License

This is an open-access article distributed under the terms of the Creative Commons Attribution CC BY 3.0 license, which permits unlimited use, distribution, and reproduction in any medium so long as the original work is properly cited.