Determination of VEGF and CXCR4 in Tumor and Peritumoral Tissue of Patients with Breast Cancer as a Predictive Factor

Authors

DOI:

https://doi.org/10.4108/eai.25-3-2022.173714

Keywords:

Breast cancer, Peritumoral tissue, CXCR-4, VEGF, Predictive factor

Abstract

INTRODUCTION: Despite the obvious progress in the field of diagnosis and therapy, further measures are needed to increase the effectiveness of treatment and reduce morbidity and mortality from breast cancer.

OBJECTIVES: To study the influence of peritumoral tissue on the growth and development of the tumor itself.

METHODS: An immunofluorescence method was used to determine the protein expression of VEGF and CXCR-4 in tumor and peritumoral tissue.

RESULTS: Peritumoral tissue is not only a passive factor, but actively participates in the process of tumor growth and development, as well as in the processes of recurrence and metastasis.

CONCLUSION: Markers of neoangiogenesis in tumor and peritumoral tissue such as protein expression of VEGF and CXCR-4 receptors may serve as reliable predictors of disease outcome in breast cancer patients, which may provide useful suggestions in treatment choices.

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Published

25-03-2022

How to Cite

Cvetković, D. ., Cvetković, A. ., Nikodijević, D. ., Jovankić, J. ., Milutinović, M. ., Stojić, V. ., Zdravković, N. ., & Mitrović, S. . (2022). Determination of VEGF and CXCR4 in Tumor and Peritumoral Tissue of Patients with Breast Cancer as a Predictive Factor. EAI Endorsed Transactions on Bioengineering and Bioinformatics, 1(4), e4. https://doi.org/10.4108/eai.25-3-2022.173714