A Review of Deep Learning Approaches for Early Diagnosis of Alzheimer's Disease

Authors

DOI:

https://doi.org/10.4108/eetel.4790

Keywords:

Deep learning, Alzheimer's Disease, Multimodal Image, Medical Image

Abstract

Alzheimer's disease (AD), one of the major neurodegenerative diseases, has become the most common cause of dementia problems. Up to now, there is a lack of effective targeted therapeutic drugs and effective treatment modalities to stop the progression of the disease. With the continuous development of computer technology, the use of computer-aided diagnostic technology tools for AD early classification studies will provide clinicians with important assistance. Deep learning-based Alzheimer's disease (AD) imaging classification has become a current research hotspot. In this paper, we first describe the commonly used publicly available datasets in the AD imaging classification task; then introduce the commonly used deep learning classification models for AD diagnosis; secondly, we compare the studies that target different biomarkers of the subjects and the use of unimodal or a combination of different modalities for the early classification of AD; and finally, The challenges of AD classification are summarized and future research directions are proposed.

References

F. Li, M. Liu, and A. s. D. N. Initiative, "A hybrid convolutional and recurrent neural network for hippocampus analysis in Alzheimer's disease," Journal of neuroscience methods, vol. 323, pp. 108-118, 2019.

Y. Zhang, "Classification of Alzheimer Disease based on structural magnetic resonance imaging by kernel support vector machine decision tree," Progress in Electromagnetics Research, vol. 144, pp. 185-191, 2014.

Y. Zhang, "Detection of Alzheimer's disease and mild cognitive impairment based on structural volumetric MR images using 3D-DWT and WTA-KSVM trained by PSOTVAC," Biomedical Signal Processing and Control, vol. 21, pp. 58-73, 2015.

M. Dünnwald, P. Ernst, E. Düzel, K. Tönnies, M. J. Betts, and S. Oeltze-Jafra, "Fully automated deep learning-based localization and segmentation of the locus coeruleus in aging and Parkinson’s disease using neuromelanin-sensitive MRI," International Journal of Computer Assisted Radiology and Surgery, vol. 16, pp. 2129-2135, 2021.

K. Imamura, Y. Yada, Y. Izumi, M. Morita, A. Kawata, T. Arisato, et al., "Prediction model of amyotrophic lateral sclerosis by deep learning with patient induced pluripotent stem cells," Annals of neurology, vol. 89, pp. 1226-1233, 2021.

E. Yee, D. Ma, K. Popuri, L. Wang, M. F. Beg, and A. s. D. N. Initiative, "Construction of MRI-based Alzheimer’s disease score based on efficient 3D convolutional neural network: Comprehensive validation on 7,902 images from a multi-center dataset," Journal of Alzheimer's Disease, vol. 79, pp. 47-58, 2021.

Y. Huang, J. Xu, Y. Zhou, T. Tong, X. Zhuang, and A. s. D. N. Initiative, "Diagnosis of Alzheimer’s disease via multi-modality 3D convolutional neural network," Frontiers in neuroscience, vol. 13, p. 509, 2019.

M. Liu, D. Zhang, D. Shen, and A. s. D. N. Initiative, "Ensemble sparse classification of Alzheimer's disease," NeuroImage, vol. 60, pp. 1106-1116, 2012.

W. Feng, N. V. Halm-Lutterodt, H. Tang, A. Mecum, M. K. Mesregah, Y. Ma, et al., "Automated MRI-based deep learning model for detection of Alzheimer’s disease process," International Journal of Neural Systems, vol. 30, p. 2050032, 2020.

M. Kavitha, N. Yudistira, and T. Kurita, "Multi instance learning via deep CNN for multi-class recognition of Alzheimer's disease," in 2019 IEEE 11th international workshop on computational intelligence and applications (IWCIA), 2019, pp. 89-94.

L. Nanni, M. Interlenghi, S. Brahnam, C. Salvatore, S. Papa, R. Nemni, et al., "Comparison of transfer learning and conventional machine learning applied to structural brain MRI for the early diagnosis and prognosis of Alzheimer's disease," Frontiers in neurology, vol. 11, p. 576194, 2020.

Y. Zhang, "Detection of Alzheimer's disease by displacement field and machine learning," PeerJ, vol. 3, Article ID: e1251, 2015.

S. Wang, "Detection of Alzheimer’s Disease by Three-Dimensional Displacement Field Estimation in Structural Magnetic Resonance Imaging," Journal of Alzheimer's Disease, vol. 50, pp. 233-248, 2016.

C. Hinrichs, V. Singh, G. Xu, and S. Johnson, "MKL for robust multi-modality AD classification," in Medical Image Computing and Computer-Assisted Intervention–MICCAI 2009: 12th International Conference, London, UK, September 20-24, 2009, Proceedings, Part II 12, 2009, pp. 786-794.

A. Chaddad, C. Desrosiers, and M. Toews, "Local discriminative characterization of MRI for Alzheimer's disease," in 2016 IEEE 13th International Symposium on Biomedical Imaging (ISBI), 2016, pp. 1-5.

I. B. Malone, D. Cash, G. R. Ridgway, D. G. MacManus, S. Ourselin, N. C. Fox, et al., "MIRIAD—Public release of a multiple time point Alzheimer's MR imaging dataset," NeuroImage, vol. 70, pp. 33-36, 2013.

Z. Li, F. Liu, W. Yang, S. Peng, and J. Zhou, "A survey of convolutional neural networks: analysis, applications, and prospects," IEEE transactions on neural networks and learning systems, 2021.

B. Khagi, G. R. Kwon, and R. Lama, "Comparative analysis of Alzheimer's disease classification by CDR level using CNN, feature selection, and machine‐learning techniques," International Journal of Imaging Systems and Technology, vol. 29, pp. 297-310, 2019.

B. Lee, W. Ellahi, and J. Y. Choi, "Using deep CNN with data permutation scheme for classification of Alzheimer's disease in structural magnetic resonance imaging (sMRI)," IEICE TRANSACTIONS on Information and Systems, vol. 102, pp. 1384-1395, 2019.

A. Nawaz, S. M. Anwar, R. Liaqat, J. Iqbal, U. Bagci, and M. Majid, "Deep convolutional neural network based classification of Alzheimer's disease using MRI data," in 2020 IEEE 23rd International Multitopic Conference (INMIC), 2020, pp. 1-6.

R. Jain, N. Jain, A. Aggarwal, and D. J. Hemanth, "Convolutional neural network based Alzheimer’s disease classification from magnetic resonance brain images," Cognitive Systems Research, vol. 57, pp. 147-159, 2019.

C. L. Saratxaga, I. Moya, A. Picón, M. Acosta, A. Moreno-Fernandez-de-Leceta, E. Garrote, et al., "MRI deep learning-based solution for Alzheimer’s disease prediction," Journal of personalized medicine, vol. 11, p. 902, 2021.

A. B. Tufail, Y.-K. Ma, and Q.-N. Zhang, "Binary classification of Alzheimer’s disease using sMRI imaging modality and deep learning," Journal of digital imaging, vol. 33, pp. 1073-1090, 2020.

A. Puente-Castro, E. Fernandez-Blanco, A. Pazos, and C. R. Munteanu, "Automatic assessment of Alzheimer’s disease diagnosis based on deep learning techniques," Computers in biology and medicine, vol. 120, p. 103764, 2020.

J. B. Bae, S. Lee, W. Jung, S. Park, W. Kim, H. Oh, et al., "Identification of Alzheimer's disease using a convolutional neural network model based on T1-weighted magnetic resonance imaging," Scientific reports, vol. 10, p. 22252, 2020.

S. H. Wang and Y. D. Lv, "Alcoholism Detection by Data Augmentation and Convolutional Neural Network with Stochastic Pooling," Journal of Medical Systems, vol. 42, Article ID: 2, 2018.

Y.-D. Zhang, "Twelve-layer deep convolutional neural network with stochastic pooling for tea category classification on GPU platform," Multimedia Tools and Applications, vol. 77, pp. 22821-22839, 2018.

A. Mechelli, C. J. Price, K. J. Friston, and J. Ashburner, "Voxel-based morphometry of the human brain: methods and applications," Current Medical Imaging, vol. 1, pp. 105-113, 2005.

M. Maqsood, F. Nazir, U. Khan, F. Aadil, H. Jamal, I. Mehmood, et al., "Transfer learning assisted classification and detection of Alzheimer’s disease stages using 3D MRI scans," Sensors, vol. 19, p. 2645, 2019.

S. Basheera and M. S. S. Ram, "Convolution neural network–based Alzheimer's disease classification using hybrid enhanced independent component analysis based segmented gray matter of T2 weighted magnetic resonance imaging with clinical valuation," Alzheimer's & Dementia: Translational Research & Clinical Interventions, vol. 5, pp. 974-986, 2019.

A. Mehmood, S. Yang, Z. Feng, M. Wang, A. S. Ahmad, R. Khan, et al., "A transfer learning approach for early diagnosis of Alzheimer’s disease on MRI images," Neuroscience, vol. 460, pp. 43-52, 2021.

H. Karasawa, C.-L. Liu, and H. Ohwada, "Deep 3d convolutional neural network architectures for alzheimer’s disease diagnosis," in Intelligent Information and Database Systems: 10th Asian Conference, ACIIDS 2018, Dong Hoi City, Vietnam, March 19-21, 2018, Proceedings, Part I 10, 2018, pp. 287-296.

W. Zhu, L. Sun, J. Huang, L. Han, and D. Zhang, "Dual attention multi-instance deep learning for Alzheimer’s disease diagnosis with structural MRI," IEEE Transactions on Medical Imaging, vol. 40, pp. 2354-2366, 2021.

T. Abuhmed, S. El-Sappagh, and J. M. Alonso, "Robust hybrid deep learning models for Alzheimer’s progression detection," Knowledge-Based Systems, vol. 213, p. 106688, 2021.

H. Sun, A. Wang, and S. He, "Temporal and spatial analysis of alzheimer’s disease based on an improved convolutional neural network and a resting-state FMRI brain functional network," International Journal of Environmental Research and Public Health, vol. 19, p. 4508, 2022.

L. Zhang, L. Wang, and D. Zhu, "Jointly Analyzing Alzheimer's Disease Related Structure-Function Using Deep Cross-Model Attention Network," in 2020 IEEE 17th International Symposium on Biomedical Imaging (ISBI), 2020, pp. 563-567.

A. Demir, T. Koike-Akino, Y. Wang, M. Haruna, and D. Erdogmus, "EEG-GNN: Graph neural networks for classification of electroencephalogram (EEG) signals," in 2021 43rd Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC), 2021, pp. 1061-1067.

J. Zhou, G. Cui, S. Hu, Z. Zhang, C. Yang, Z. Liu, et al., "Graph neural networks: A review of methods and applications," AI open, vol. 1, pp. 57-81, 2020.

S. Parisot, S. I. Ktena, E. Ferrante, M. Lee, R. Guerrero, B. Glocker, et al., "Disease prediction using graph convolutional networks: application to autism spectrum disorder and Alzheimer’s disease," Medical image analysis, vol. 48, pp. 117-130, 2018.

X. Li, Y. Zhou, N. C. Dvornek, M. Zhang, J. Zhuang, P. Ventola, et al., "Pooling regularized graph neural network for fmri biomarker analysis," in Medical Image Computing and Computer Assisted Intervention–MICCAI 2020: 23rd International Conference, Lima, Peru, October 4–8, 2020, Proceedings, Part VII 23, 2020, pp. 625-635.

X. Bi, Z. Liu, Y. He, X. Zhao, Y. Sun, and H. Liu, "GNEA: a graph neural network with ELM aggregator for brain network classification," Complexity, vol. 2020, pp. 1-11, 2020.

C. Yang, P. Wang, J. Tan, Q. Liu, and X. Li, "Autism spectrum disorder diagnosis using graph attention network based on spatial-constrained sparse functional brain networks," Computers in Biology and Medicine, vol. 139, p. 104963, 2021.

L. Li, H. Jiang, G. Wen, P. Cao, M. Xu, X. Liu, et al., "TE-HI-GCN: An ensemble of transfer hierarchical graph convolutional networks for disorder diagnosis," Neuroinformatics, pp. 1-23, 2021.

A. YİĞİT and Z. Işik, "Applying deep learning models to structural MRI for stage prediction of Alzheimer's disease," Turkish Journal of Electrical Engineering and Computer Sciences, vol. 28, pp. 196-210, 2020.

X. Bi, S. Li, B. Xiao, Y. Li, G. Wang, and X. Ma, "Computer aided Alzheimer's disease diagnosis by an unsupervised deep learning technology," Neurocomputing, vol. 392, pp. 296-304, 2020.

H. Guo and Y. Zhang, "Resting state fMRI and improved deep learning algorithm for earlier detection of Alzheimer’s disease," IEEE Access, vol. 8, pp. 115383-115392, 2020.

H. S. Parmar, B. Nutter, R. Long, S. Antani, and S. Mitra, "Deep learning of volumetric 3D CNN for fMRI in Alzheimer’s disease classification," in Medical Imaging 2020: Biomedical Applications in Molecular, Structural, and Functional Imaging, 2020, pp. 66-71.

X. Bi, X. Zhao, H. Huang, D. Chen, and Y. Ma, "Functional brain network classification for Alzheimer’s disease detection with deep features and extreme learning machine," Cognitive Computation, vol. 12, pp. 513-527, 2020.

F. Gao, "Integrated positron emission tomography/magnetic resonance imaging in clinical diagnosis of Alzheimer’s disease," European Journal of Radiology, vol. 145, p. 110017, 2021.

G. D. Rabinovici, C. Gatsonis, C. Apgar, K. Chaudhary, I. Gareen, L. Hanna, et al., "Association of amyloid positron emission tomography with subsequent change in clinical management among medicare beneficiaries with mild cognitive impairment or dementia," Jama, vol. 321, pp. 1286-1294, 2019.

A. Punjabi, A. Martersteck, Y. Wang, T. B. Parrish, A. K. Katsaggelos, and A. s. D. N. Initiative, "Neuroimaging modality fusion in Alzheimer’s classification using convolutional neural networks," PloS one, vol. 14, p. e0225759, 2019.

J. Zhang, X. He, Y. Liu, Q. Cai, H. Chen, and L. Qing, "Multi-modal cross-attention network for Alzheimer’s disease diagnosis with multi-modality data," Computers in Biology and Medicine, vol. 162, p. 107050, 2023.

Y. Zhang, X. He, Y. H. Chan, Q. Teng, and J. C. Rajapakse, "Multi-modal graph neural network for early diagnosis of Alzheimer's disease from sMRI and PET scans," Computers in Biology and Medicine, vol. 164, p. 107328, 2023.

P. Forouzannezhad, A. Abbaspour, C. Li, M. Cabrerizo, and M. Adjouadi, "A deep neural network approach for early diagnosis of mild cognitive impairment using multiple features," in 2018 17th IEEE international conference on machine learning and applications (ICMLA), 2018, pp. 1341-1346.

L. Kang, J. Jiang, J. Huang, and T. Zhang, "Identifying early mild cognitive impairment by multi-modality MRI-based deep learning," Frontiers in aging neuroscience, vol. 12, p. 206, 2020.

A. Khvostikov, K. Aderghal, J. Benois-Pineau, A. Krylov, and G. Catheline, "3D CNN-based classification using sMRI and MD-DTI images for Alzheimer disease studies," arXiv preprint arXiv:1801.05968, 2018.

Y. Zhang, "Three-Dimensional Eigenbrain for the Detection of Subjects and Brain Regions Related with Alzheimer’s Disease," Journal of Alzheimer's Disease, vol. 50, pp. 1163-1179, 2016.

Downloads

Published

16-01-2024

How to Cite

[1]
M. Xi, “A Review of Deep Learning Approaches for Early Diagnosis of Alzheimer’s Disease”, EAI Endorsed Trans e-Learn, vol. 9, Jan. 2024.