Exploring the Potential of Deep Learning in the Classification and Early Detection of Parkinson's Disease

Authors

DOI:

https://doi.org/10.4108/eetpht.10.5568

Keywords:

Parkinson's Disease, ResNet50, VGG16, Inception v2, AlexNet, VGG19, DL, accuracy, healthcare

Abstract

INTRODUCTION: Parkinson's Disease (PD) is a progressive neurological disorder affecting a significant portion of the global population, leading to profound impacts on daily life and imposing substantial burdens on healthcare systems. Early identification and precise classification are crucial for effectively managing this disease. This research investigates the potential of deep learning techniques in facilitating early recognition and accurate classification of PD.

OBJECTIVES: The primary objective of this study is to leverage advanced deep learning techniques for the early detection and precise classification of Parkinson's Disease. By utilizing a rich dataset comprising speech signal features extracted from 3000 PD patients, including Time Frequency Features, Mel Frequency Cepstral Coefficients (MFCCs), Wavelet Transform based Features, Vocal Fold Features, and TWQT features, this research aims to evaluate the performance of various deep learning models in PD classification.

METHODS: The dataset containing diverse speech signal features from PD patients' recordings serves as the foundation for training and evaluating five different deep learning models: ResNet50, VGG16, Inception v2, AlexNet, and VGG19. Each model undergoes training and assessment to determine its capability in accurately classifying PD patients. Performance metrics such as accuracy are employed to evaluate the models' effectiveness.

RESULTS: The results demonstrate promising potential, with overall accuracies ranging from 89% to 95% across the different deep learning models. Notably, AlexNet emerges as the top-performing model, achieving an accuracy of 95% and demonstrating balanced performance in accurately identifying both true and false PD cases.

CONCLUSION: This research highlights the significant potential of deep learning in facilitating the early detection and classification of Parkinson's Disease. Leveraging speech signal features offers a non-invasive and cost-effective approach to PD assessment. The findings contribute to the growing body of evidence supporting the integration of artificial intelligence in healthcare, particularly in the realm of neurodegenerative disorders. Further exploration into the application of deep learning in this domain holds promise for advancing PD diagnosis and management.

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References

Classification of fluctuations in patients with Parkinson's disease Niall P. Quinn Neurology Aug 1998, 51 (2 Suppl 2) S25-S29; DOI: 10.1212/WNL.51.2_Suppl_2.S25 DOI: https://doi.org/10.1212/WNL.51.2_Suppl_2.S25

A Tsanas, M. A. Little, P. E. McSharry, J. Spielman and L. O. Ramig, "Novel Speech Signal Processing Algorithms for High-Accuracy Classification of Parkinson's Disease," in IEEE Transactions on Biomedical Engineering, vol. 59, no. 5, pp. 1264-1271, May 2012, doi: 10.1109/TBME.2012.2183367 DOI: https://doi.org/10.1109/TBME.2012.2183367

Pasha, A., Latha, P.H. Bio-inspired dimensionality reduction for Parkinson’s disease (PD) classification. Health Inf Sci Syst 8, 13 (2020). https://doi.org/10.1007/s13755-020-00104-w DOI: https://doi.org/10.1007/s13755-020-00104-w

Yuanxi Li, & Tucker, A. (2010). Uncovering disease regions using pseudo time-series trajectories on clinical trial data. 2010 3rd International Conference on Biomedical Engineering and Informatics, 6, 2356–2362. https://doi.org/10.1109/BMEI.2010.5639726 DOI: https://doi.org/10.1109/BMEI.2010.5639726

Drotár, J. Mekyska, I. Rektorová, L. Masarová, Z. Smékal and M. Faundez-Zanuy, "A new modality for quantitative evaluation of Parkinson's disease: In-air movement," , Chania, Greece, 2013, pp. 1-4, doi: 10.1109/BIBE.2013.6701692. DOI: https://doi.org/10.1109/BIBE.2013.6701692

Rehman, R.Z.U., Del Din, S., Guan, Y. et al. Selecting Clinically Relevant Gait Characteristics for Classification of Early Parkinson’s Disease: A Comprehensive Machine Learning Approach. Sci Rep 9, 17269 (2019). https://doi.org/10.1038/s41598-019-53656-7 DOI: https://doi.org/10.1038/s41598-019-53656-7

Acharya, U.R., Hagiwara, Y., Deshpande, S.N., Suren, S., Koh, J.E.W., Oh, S.L., Arunkumar, N., Ciaccio, E.J., & Lim, C.M. (2018). Characterization of focal EEG signals: a review. Future Generation Computer Systems. https://doi.org/10.1016/j.future.2018.08.044 DOI: https://doi.org/10.1016/j.future.2018.08.044

Oh, S.L., Hagiwara, Y., Raghavendra, U. et al. A deep learning approach for Parkinson’s disease diagnosis from EEG signals. Neural Comput & Applic 32, 10927–10933 (2020). https://doi.org/10.1007/s00521-018-3689-5 DOI: https://doi.org/10.1007/s00521-018-3689-5

Jayakrishna S Madabushi, Mayank Gupta, Brett Pearce, Nihit Gupta, Parkinson’s Disease: Diagnostic Challenges Amidst Transdiagnostic and Overlapping Mental Health Symptoms, Cureus, 10.7759/cureus.36661, (2023). DOI: https://doi.org/10.7759/cureus.36661

Matthieu Béreau, Vincent Van Waes, Mathieu Servant, Eloi Magnin, Laurent Tatu, Mathieu Anheim, Apathy in Parkinson’s Disease: Clinical Patterns and Neurobiological Basis, Cells, 10.3390/cells12121599, 12, 12, (1599), (2023). DOI: https://doi.org/10.3390/cells12121599

Jiang-ting Li, Yi Qu, Hong-ling Gao, Jing-yi Li, Qi-xiong Qin, Dan-lei Wang, Jing-wei Zhao, Zhi-juan Mao, Zhe Min, Yong-jie Xiong, Zheng Xue, "A nomogram based on iron metabolism can help identify apathy in patients with Parkinson’s disease," Frontiers in Aging Neuroscience, 10.3389/fnagi.2022.1062964, 14, (2023).

Emmie Cohen, Allison A. Bay, Liang Ni, Madeleine E. Hackney, Apathy-Related Symptoms Appear Early in Parkinson’s Disease, Healthcare, 10.3390/healthcare10010091, 10, 1, (91), (2022). DOI: https://doi.org/10.3390/healthcare10010091

Haikun Xu, Mengchao Zhang, Ziju Wang, Yanyan Yang, Ying Chang, Lin Liu, Abnormal brain activities in multiple frequency bands in Parkinson’s disease with apathy, Frontiers in Neuroscience, 10.3389/fnins.2022.975189, 16, (2022) DOI: https://doi.org/10.3389/fnins.2022.975189

Jaime Kulisevsky, Saul Martínez-Horta, Antonia Campolongo, Berta Pascual-Sedano, Juan Marín-Lahoz, Helena Bejr-kasem, Ignacio Aracil-Bolaños, Andrea Horta-Barba, Arnau Puig-Davi, Javier Pagonabarraga, A Randomized Clinical Trial to Evaluate the Effects of Safinamide on Apathetic Non-demented Patients With Parkinson's Disease, Frontiers in Neurology, 10.3389/fneur.2022.866502, 13, (2022). DOI: https://doi.org/10.3389/fneur.2022.866502

Gulnara Zh. Makhmudova, Niinoya I.N. Vellovich, Elena V. Shirshova, Affective disorders and сognitive impairment in the early stages of Parkinson’s disease, Journal of Clinical Practice, 10.17816/clinpract100026, 13, 2, (37-44), (2022). DOI: https://doi.org/10.17816/clinpract100026

Daniel Weintraub, Dag Aarsland, Roberta Biundo, Roseanne Dobkin, Jennifer Goldman, Simon Lewis,, Management of psychiatric and cognitive complications in Parkinson’s disease, BMJ, 10.1136/bmj-2021-068718, (e068718), (2022). DOI: https://doi.org/10.1136/bmj-2021-068718

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Published

27-03-2024

How to Cite

1.
Bakkialakshmi VS, Arulalan V, Chinnaraju G, Ghosh H, Rahat IS, Saha A. Exploring the Potential of Deep Learning in the Classification and Early Detection of Parkinson’s Disease. EAI Endorsed Trans Perv Health Tech [Internet]. 2024 Mar. 27 [cited 2024 May 3];10. Available from: https://publications.eai.eu/index.php/phat/article/view/5568