Eye Disease Detection Using Deep Learning Models with Transfer Learning Techniques

Authors

  • Bhavadharini R.M. Vellore Institute of Technology University image/svg+xml
  • Kalla Bharath Vardhan Vellore Institute of Technology University image/svg+xml
  • Mandava Nidhish Vellore Institute of Technology University image/svg+xml
  • Surya Kiran C. Vellore Institute of Technology University image/svg+xml
  • Dudekula Nahid Shameem Vellore Institute of Technology University image/svg+xml
  • Varanasi Sai Charan Vellore Institute of Technology University image/svg+xml

DOI:

https://doi.org/10.4108/eetsis.5971

Keywords:

Deep Learning (DL), Transfer Learning (TL), CNN, VGG19, ResNet50, InceptionV3, Cataract, Diabetic Retinopathy, Glaucoma

Abstract

INTRODUCTION: Diabetic Retinopathy, Cataract and Glaucoma are the major eye diseases posing significant diagnostic challenges due to their asymptotic nature at their early stages. These diseases if not detected and diagnosed at their early stages may lead to severe visual impairment and even can cause blindness in human beings. Early detection of eye diseases showed an exceptional recovery rate. Traditional diagnostic methods primarily relying on expertise in the field of ophthalmology involve a time-consuming process. With technological advancements in the field of imaging techniques, a large volume of medical images have been created which can be utilized for developing more accurate diagnostic tools in the field. Deep learning (DL) models are playing a significant role in analyzing medical images. DL algorithms can automatically learn the features which indicate eye diseases from eye image datasets. Training DL models, however, requires a significant amount of data and computational resources. To overcome this, we use advanced deep learning algorithms combined with transfer-learning techniques. Leveraging the power of deep learning, we aim to develop sophisticated models that can distinguish different eye diseases in medical image data.

OBJECTIVES: To improve the accuracy and efficiency of early detection methods, improve diagnostic precision, and intervene in these challenging ocular conditions in a timely manner.

METHODS: The well-known Deep Learning architectures VGG19, InceptionV3 and ResNet50 architectures with transfer learning were evaluated and the results are compared.

RESULTS: VGG19, InceptionV3 and ResNet50 architectures with transfer learning achieved 90.33%, 89.8% and 99.94% accuracies, respectively. The precision, recall, and F1 scores for VGG19 were recorded as 79.17%, 79.17%, and 78.21%, while InceptionV3 showed 82.56%, 82.38%, and 82.11% and ResNet50 has 96.28%, 96.2%, and 96.24%.

CONCLUSION: The Convolutional Neural Network models VGG19, Inception v3, ResNet50 combined with transfer learning achieve better results than the original Convolutional Neural Network models.

References

Jayachitra S, Kanna KN, Pavithra G, Ranjeetha T. A novel eye cataract diagnosis and classification using deep neural network. In Journal of Physics: Conference Series 2021 Jun 1 (Vol. 1937, No. 1, p. 012053). IOP Publishing.

Obana A, Ote K, Hashimoto F, Asaoka R, Gohto Y, Okazaki S, Yamada H. Correction for the influence of cataract on macular pigment measurement by autofluorescence technique using deep learning. Translational vision science & technology. 2021 Feb 5;10(2):18-18.

Simonyan, K., & Zisserman, A, Very Deep Convolutional Networks for Large-Scale Image Recognition. CoRR, abs/1409.1556, 2014.

He K, Zhang X, Ren S, Sun J. Deep residual learning for image recognition. In Proceedings of the IEEE conference on computer vision and pattern recognition, pp. 770-778,2016.

Szegedy C, Vanhoucke V, Ioffe S, Shlens J, Wojna Z. Rethinking the inception architecture for computer vision. InProceedings of the IEEE conference on computer vision and pattern recognition, pp. 2818-2826, 2016.

Saju B, Rajesh R. Eye-Vision Net: Cataract Detection and Classification in Retinal and Slit Lamp Images using Deep Network. International Journal of Advanced Computer Science and Applications. 2022;13(12).

Hu S, Luan X, Wu H, Wang X, Yan C, Wang J, Liu G, He W. ACCV: automatic classification algorithm of cataract video based on deep learning. BioMedical Engineering OnLine. 2021 Dec; 20:1-7.

ÇETİNER H. Cataract disease classification from fundus images with transfer learning based deep learning model on two ocular disease datasets. Gümüşhane Üniversitesi Fen Bilimleri Dergisi. 2023 Jan;13(2):258-69.

Zhang L, Li J, Han H, Liu B, Yang J, Wang Q. Automatic cataract detection and grading using deep convolutional neural network. In2017 IEEE 14th international conference on networking, sensing and control (ICNSC) 2017 May 16 (pp. 60-65).

Pratap T, Kokil P. Computer-aided diagnosis of cataract using deep transfer learning. Biomedical Signal Processing and Control. 2019 Aug 1;53:101533.

Dong Y, Zhang Q, Qiao Z, Yang JJ. Classification of cataract fundus image based on deep learning. In 2017 IEEE international conference on imaging systems and techniques (IST) 2017 Oct 18 (pp. 1-5).

Ran J, Niu K, He Z, Zhang H, Song H. Cataract detection and grading based on combination of deep convolutional neural network and random forests. In 2018 IEEE international conference on network infrastructure and digital content (IC-NIDC) 2018 Aug 22 (pp. 155-159).

Elloumi Y. Mobile aided system of deep-learning based cataract grading from fundus images. InArtificial Intelligence in Medicine: 19th International Conference on Artificial Intelligence in Medicine, AIME 2021, Virtual Event, June 15–18, 2021, Proceedings 2021 (pp. 355-360). Springer International Publishing.

Alyoubi WL, Abulkhair MF, Shalash WM. Diabetic retinopathy fundus image classification and lesions localization system using deep learning. Sensors. 2021 May 26;21(11):3704.

Ghan G, Chavan S, Chaudhari A. Diabetic retinopathy classification using deep learning. In2020 Fourth International Conference on Inventive Systems and Control (ICISC) 2020 Jan 8 (pp. 761-765).

Butt MM, Iskandar DA, Abdelhamid SE, Latif G, Alghazo R. Diabetic retinopathy detection from fundus images of the eye using hybrid deep learning features. Diagnostics. 2022 Jul 1;12(7):1607.

Bilal A, Zhu L, Deng A, Lu H, Wu N. AI-based automatic detection and classification of diabetic retinopathy using U-Net and deep learning. Symmetry. 2022 Jul 12;14(7):1427.

Pinedo-Diaz G, Ortega-Cisneros S, Moya-Sanchez EU, Rivera J, Mejia-Alvarez P, Rodriguez-Navarrete FJ, Sanchez A. Suitability classification of retinal fundus images for diabetic retinopathy using deep learning. Electronics. 2022 Aug 17;11(16):2564.

Li X, Pang T, Xiong B, Liu W, Liang P, Wang T. Convolutional neural networks based transfer learning for diabetic retinopathy fundus image classification. In2017 10th international congress on image and signal processing, biomedical engineering and informatics (CISP-BMEI) 2017 Oct 14 (pp. 1-11). IEEE.

Sahlsten J, Jaskari J, Kivinen J, Turunen L, Jaanio E, Hietala K, Kaski K. Deep learning fundus image analysis for diabetic retinopathy and macular edema grading. Scientific reports. 2019 Jul 24;9(1):10750.

Xu K, Feng D, Mi H. Deep convolutional neural network-based early automated detection of diabetic retinopathy using fundus image. Molecules. 2017 Nov 23;22(12):2054.

Yang Y, Li T, Li W, Wu H, Fan W, Zhang W. Lesion detection and grading of diabetic retinopathy via two-stages deep convolutional neural networks. In Medical Image Computing and Computer Assisted Intervention− MICCAI 2017: 20th International Conference, Quebec City, QC, Canada, September 11-13, 2017, Proceedings, Part III 20 2017 (pp. 533-540). Springer International Publishing.

Pires R, Avila S, Wainer J, Valle E, Abramoff MD, Rocha A. A data-driven approach to referable diabetic retinopathy detection. Artificial intelligence in medicine. 2019 May 1;96:93-106.

Kashyap R, Nair R, Gangadharan SM, Botto-Tobar M, Farooq S, Rizwan A. Glaucoma detection and classification using improved U-Net Deep Learning Model. InHealthcare 2022 Dec 9 (Vol. 10, No. 12, p. 2497). MDPI.

Sandoval-Cuellar HJ, Alfonso-Francia G, Vázquez-Membrillo MA, Ramos-Arreguín JM, Tovar-Arriaga S. Image-based glaucoma classification using fundus images and deep learning. Revista mexicana de ingeniería biomédica. 2021 Dec;42(3).

Naidana KS, Barpanda SS. Glaucoma classification using a polynomial-driven deep learning approach. Bulletin of Electrical Engineering and Informatics. 2023 Aug 1;12(4):2245-61.

Schottenhamml J, Würfl T, Mardin S, Ploner SB, Husvogt L, Hohberger B, Lämmer R, Mardin C, Maier A. Glaucoma classification in 3 x 3 mm en face macular scans using deep learning in different plexus. Biomedical optics express. 2021 Dec 1;12(12):7434-44.

Sułot D, Alonso-Caneiro D, Ksieniewicz P, Krzyzanowska-Berkowska P, Iskander DR. Glaucoma classification based on scanning laser ophthalmoscopic images using a deep learning ensemble method. Plos one. 2021 Jun 4;16(6):e0252339.

Hemanth DJ, Deperlioglu O, Kose U. An enhanced diabetic retinopathy detection and classification approach using deep convolutional neural network. Neural Computing and Applications. 2020 Feb;32(3):707-21.

Phan, S., Satoh, S.I., Yoda, Y., Kashiwagi, K. and Oshika, T., 2019. Evaluation of deep convolutional neural networks for glaucoma detection. Japanese journal of ophthalmology, 63, pp.276-283.

An G, Omodaka K, Hashimoto K, Tsuda S, Shiga Y, Takada N, Kikawa T, Yokota H, Akiba M, Nakazawa T. Glaucoma diagnosis with machine learning based on optical coherence tomography and color fundus images. Journal of healthcare engineering. 2019;2019(1):4061313.

Diaz-Pinto A, Morales S, Naranjo V, Köhler T, Mossi JM, Navea A. CNNs for automatic glaucoma assessment using fundus images: an extensive validation. Biomedical engineering online. 2019 Dec;18:1-9.

Pal A, Moorthy MR, Shahina A. G-eyenet: A convolutional autoencoding classifier framework for the detection of glaucoma from retinal fundus images. In2018 25th IEEE international conference on image processing (ICIP) 2018 Oct 7 (pp. 2775-2779).

Smaida M, Serhii Y. Comparative Study of Image Classification Algorithms for Eyes Diseases Diagnostic. International Journal of Innovative Science and Research Technology. 2019 Dec;4(12).

Nazir T, Nawaz M, Rashid J, Mahum R, Masood M, Mehmood A, Ali F, Kim J, Kwon HY, Hussain A. Detection of diabetic eye disease from retinal images using a deep learning based CenterNet model. Sensors. 2021 Aug 5;21(16):5283.

Chelaramani S, Gupta M, Agarwal V, Gupta P, Habash R. Multi-task knowledge distillation for eye disease prediction. InProceedings of the IEEE/CVF Winter Conference on Applications of Computer Vision 2021 (pp. 3983-3993).

Sarki R, Ahmed K, Wang H, Zhang Y, Ma J, Wang K. Image preprocessing in classification and identification of diabetic eye diseases. Data Science and Engineering. 2021 Dec;6(4):455-71.

Tan M, Le Q. Efficientnet: Rethinking model scaling for convolutional neural networks. In International conference on machine learning 2019 May 24 (pp. 6105-6114). PMLR.

Krishna ST, Kalluri HK. Deep learning and transfer learning approaches for image classification. International Journal of Recent Technology and Engineering (IJRTE). 2019 Feb;7(5S4):427-32.

Elsharif, A. A. E. F., Abu-Naser, S. S, Retina Diseases Diagnosis Using Deep Learning, International Journal of Academic Engineering Research, Vol.6, Issue. 2, 2022. DOI:10.33022/ijcs.v13i1.3731

Yaqoob MK, Ali SF, Bilal M, Hanif MS, Al-Saggaf UM. ResNet based deep features and random forest classifier for diabetic retinopathy detection. Sensors. 2021 Jun 4;21(11):3883.

Kim J, Tran L. Retinal disease classification from oct images using deep learning algorithms. In2021 IEEE Conference on Computational Intelligence in Bioinformatics and Computational Biology (CIBCB) 2021 Oct 13 (pp. 1-6). IEEE.

Choi JY, Yoo TK, Seo JG, Kwak J, Um TT, Rim TH. Multi-categorical deep learning neural network to classify retinal images: A pilot study employing small database. PloS one. 2017 Nov 2;12(11):e0187336.

Sarki R, Ahmed K, Wang H, Zhang Y, Wang K. Convolutional neural network for multi-class classification of diabetic eye disease. EAI Endorsed Transactions on Scalable Information Systems. 2021 Dec 16;9(4).

Sarki R, Ahmed K, Wang H, Zhang Y. Automated detection of mild and multi-class diabetic eye diseases using deep learning. Health Information Science and Systems. 2020 Oct 8;8(1):32.

Sarki R, Ahmed K, Wang H, Zhang Y. Automatic detection of diabetic eye disease through deep learning using fundus images: a survey. IEEE access. 2020 Aug 10;8:151133-49.

Downloads

Published

19-07-2024

How to Cite

1.
R.M. B, Vardhan KB, Nidhish M, Kiran C. S, Nahid Shameem D, Sai Charan V. Eye Disease Detection Using Deep Learning Models with Transfer Learning Techniques. EAI Endorsed Scal Inf Syst [Internet]. 2024 Jul. 19 [cited 2024 Jul. 26];11. Available from: https://publications.eai.eu/index.php/sis/article/view/5971

Issue

Section

Research articles